Ctgf tumor
WebApr 7, 2024 · Recently, CTGF was also found to play an important role in the growth of bone metastases from prostate and breast cancer through forming CTGF–Runx2–RANKL axis 37. WebApr 12, 2024 · Hepatic cancer is one of the deadliest malignancies throughout the world, ... The expression of CTGF, the most classical Hippo target gene, was used as the readout. (Fig. 1A).
Ctgf tumor
Did you know?
WebOf late, there is accumulating evidence that CTGF expression is highly correlated with the development of cancers. 5 Elevated CTGF expression has been observed in mammary … WebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to …
WebElevated CTGF expression has been detected in many tumor types [5,17] where it has been identified as an invasion-specific gene [18] and is highly expressed within the neoplastic epithelium of PDAC [9]. Wenger et al. showed 59-fold enhancement of CTGF expression in 15 out of 19 samples of pancreatic tumors, compared with only 4.5-fold WebApr 20, 2024 · a The efficacies of the first-line anti-cancer drugs (Cisplatin and 5-FU) were assessed on GC cells after knocking down AMOTL1, YAP1, CTGF, and control, respectively. b The IC 50 of VP was ...
WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … WebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells …
WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM remodeling and angiogenesis. We demonstrate a robust induction of CTGF synthesis and secretion in response to serum factors that is enabled only when MUC1 is highly expressed.
WebMar 21, 2024 · These eight phenotypes are “TNF- CTGF- GLUT4+”, “TNF- CTGF+ GLUT4-”, “TNF- CTGF+ GLUT4+”, “TNF+ CTGF- GLUT4-”, “TNF+ CTGF- GLUT4+”, “TNF+ CTGF+ GLUT4-”, ... M2 and tumor-associated macrophages (TAMs) type M1 (M1-TAM) and type M2 (M2-TAM) (Figure 1E). Using this computational approach, we found that insulin … dan river mills schoolfield complexWebJul 8, 2013 · Accordingly, we investigated the function of connective tissue growth factor (CTGF), a protein known to be important in stromal formation. CTGF is a pleiotropic and cysteine-rich matricellular protein that is abundant in many solid malignancies including pancreas, breast, esophageal, glioblastoma, and hepatocellular carcinoma ( 18 – 23 ). dan river high footballWebConnective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. ... CCN2 inhibits lung cancer … dan river sheets pricesWebMar 31, 2011 · These studies suggest that Cyr61 and CTGF are 2 critical TAZ transcriptional targets mediating TAZ-induced drug resistance in breast cancer cells. Together, our studies provided the first biological evidence that overexpression of the TAZ oncogene can cause drug resistance of breast cancer cells through direct activation of 2 secreted and ... dan river fly fishingWebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth … dan river mills schoolfield siteWebMay 10, 2024 · Our findings suggest that CTGF is a marker for medulloblastoma independent of molecular subgroups and its transcriptional program is active at the … dan river churchWebSep 15, 2024 · Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth … birthday party ideas for 10 year old