Cisplatin hearing loss data
WebAfter the first cycle of cisplatin, in the placebo ears, 76% of patients experienced hearing loss in the clinical frequency range that met the ototoxicity criteria established by the American Speech-Language-Hearing Association. WebDec 11, 2024 · It is used for the treatment of a variety of cancers such as cervical, breast, stomach, prostate, bladder and oesophageal, to name a few. However due to its expansive toxicity profile, patients receiving cisplatin can experience high frequency hearing loss, a side effect known as ototoxicity.
Cisplatin hearing loss data
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WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease … Web顺铂治疗导致的永久性听力损失率在 40% 到 80% 之间，并且与相当大的发病率和对生活质量的负面影响有关。 目前，没有 FDA 批准的预防顺铂引起的听力损失的疗法。 HMG-CoA 还原酶抑制剂（他汀类药物）由于假定的多效性作用、减少炎症和氧化应激而受到关注。 一些临床前和回顾性研究表明，同时服用他汀类药物可以减少顺铂相关的听力损失。 目的： …
WebThirteen percent sustained a significant hearing handicap. An interindividual variation was found, ranging from severe hearing loss after the first course to unaffected hearing after … WebApr 7, 2024 · The benefit of Pedmarqsi is preventing cisplatin-induced hearing loss, as evaluated in a phase III, randomised, open-label study in children with standard-risk hepatoblastoma and treated with cisplatin alone or in combination with Pedmarqsi. The most common side effects are vomiting, nausea, hypernatraemia, hypophosphataemia …
WebJun 1, 2024 · Overall, for all cancers treated with cisplatin, the incidence of hearing loss is about 50%. But some specific cancers, especially children who have cancers in very early childhood—say, younger than 5 years old—tend to have a more severe cisplatin-induced hearing loss and at a higher incidence. WebFeb 11, 2024 · Cisplatin-induced hearing loss (CIHL) is a debilitating toxicity commonly experienced by patients who received cisplatin …
WebModern research on ototoxicity goes back to the 1940s, when streptomycin was introduced into clinical practice. Today, aminoglycoside antibiotics and platinum-based chemotherapy, mainly cisplatin, are the most important drugs that …
WebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs ( Spankovich et al., 2016 ). In an alternative rodent experiment, the otoprotective effect of hypothermia applied through a custom-made cooling device was evaluated in a cochlea implantation situation. inclusion support portal login nswWebTaking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10(-8), hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, inclusion support newcastleWebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to … inclusion support program gnbWebOct 11, 2024 · The incidence of hearing loss in humans after aminoglycoside treatment remains unclear due to variable dose stratification regimens and limited pure-tone testing … inclusion support offer kirkleesWebSep 1, 2024 · Improving Ototoxicity Monitoring with Cisplatin Therapy at VA Northeast Ohio Healthcare System (VANOHS), An Interdisciplinary Team Approach. Publish date: September 1, 2024. Author(s): Lisa Arfons, MD Yasmine Ayoub, PharmD, BCPS Deborah Fox, RN, BSN, MSHS Jill Lagerstedt, MA, CCC-A, Clinical Audiologist inclusion support service kentWebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is … inclusion support tasmaniaWebFeb 24, 2024 · Cisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of … inclusion support staff