Canine model of pacing-induced heart failure

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August undefined, 2024

WebMar 20, 2001 · The canine pacing-induced heart failure model shows a pattern of E-C coupling changes similar to that of humans: I Ca,L of normal amplitude triggers Ca i transients and contractions much smaller than normal, whereas SR Ca uptake is markedly impaired. 11 The present study investigates whether the defect in E-C coupling is due to … WebFeb 1, 2004 · Heart failure was induced in 15 dogs over 27 days by rapid pacing (230 beats/min). Seven animals underwent sham surgery, and 8 animals received 3 transventricular Myosplint devices each.

Canine Model of Pacing-Induced Heart Failure Request …

WebJun 13, 2005 · Animal Model Preparation. All procedures were approved by the Indiana University Institutional Animal Care and Utilization Committee. The study was performed in a canine model of healed myocardial infarction (MI) and pacing-induced heart failure (HF) that was shown to have a high incidence of spontaneous ischemic ventricular … WebThe mechanisms of sinoatrial node (SAN) dysfunction in heart failure (HF) remain unclear. We hypothesized that impaired rhythmic spontaneous sarcoplasmic reticulum Ca(2+) … bool leapyear int

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WebJul 1, 2024 · The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. J Pharmacol … WebThe LVEDP increased and impedance decreased during pacing-induced heart failure and recovered after pacing cessation. At the end of pacing, there was a mean impedance reduction of 10.6 +/- 8.3% and a mean LVEDP increase of 18.1 +/- 4.5 mmHg compared to baseline. The impedance and LVEDP were inversely correlated (r =-0.41 to -0.85, all P < … WebJan 15, 2016 · Background: Our aim was to assess how atrial fibrillation (AF) induction, chronicity, and RR interval irregularity affect left atrial (LA) function and size in the setting of underlying heart failure (HF), and to determine whether AF effects can be mitigated by vagal nerve stimulation (VNS). Methods: HF was induced by 4-weeks of rapid … bool leapyear int year

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Ca2+ clock malfunction in a canine model of pacing …

WebJul 1, 2024 · The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. J Pharmacol Exp Ther. (1997) 282:23–31. PubMed Abstract Google Scholar. ... 34. Powers JC, Recchia F. Canine model of pacing-induced heart failure. Methods Mol Biol. (2024) … WebMyocardial Akt levels were elevated in early heart failure (after 1-2 weeks of pacing) accompanied by increased levels of oxidative stress, cytokine tumor necrosis factor-alpha (TNF-alpha) and free fatty acid accumulation, reduced activity levels of mitochondrial respiratory complexes III and V and apoptosis initiation. hashing in c codeWebThe aim of the study was to use the isolated blood-perfused rat heart to: (i) determine whether brief intermittent rapid pacing and ventricular fibrillation ar 掌桥科研一站式科研服务平台 hashing in advanced data structure

"WebThis model typically produces heart failure as defined by an LV dP/dt max <1500 mmHg/s, end-diastolic pressure >25 mmHg, mean arterial pressure <85 mmHg, and an ejection … " - Canine model of pacing-induced heart failure

Canine model of pacing-induced heart failure

Ca2+ clock malfunction in a canine model of pacing …

WebChronic heart failure is a clinical syndrome with multiple etiologies, associated with significant morbidity and mortality. Cardiac arrhythmias, including ventricular tachyarrhythmias and atrial fibrillation, are common in heart failure. A number of cardiac diseases including heart failure alter the expression and regulation of ion channels and … WebTo further understand the cellular events and to clarify their role in the pathology of cardiac failure, we have examined mitochondrial enzymatic function and peptide content, and mitochondrial DNA (mtDNA) integrity in a canine model of pacing-induced cardiac failure. Methods: Myocardium and skeletal muscle tissues were evaluated for levels of ...

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WebAug 21, 2010 · Second, we used a pacing-induced heart failure canine model to observe the global and RWM abnormalities after long-term (2 months) rapid pacing (180/min). The patient and canine results were compared to see if the canine model reproduced the findings in patients. WebJan 31, 2024 · Heart failure (HF) has been proposed as a potential indication of renal denervation (RDN). However, the mechanisms enabling RDN to attenuate HF are not well understood, especially the central …

WebChronic rapid ventricular pacing (250 beats/min) induces severe heart failure in a canine model. To assess the potential for recovery after cessation of pacing, simultaneous hemodynamic and two-dimensional echocardiographic studies were conducted in nine conscious dogs paced to severe heart failure (4.3 +/- 1.7 weeks). WebTachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of …

WebJan 31, 2024 · The Impact of Renal Denervation on the Progression of Heart Failure in a Canine Model Induced by Right Ventricular Rapid Pacing The Impact of Renal Denervation on the Progression of Heart Failure in a Canine Model Induced by Right Ventricular Rapid Pacing Front Physiol. 2024 Jan 31;10:1625. doi: … WebHeart failure with reduced ejection fraction (HFrEF) is defined by an ejection fraction (EF) below 40%. Many distinct disease processes culminate in HFrEF, among them acute and chronic ischemia, pressure …

WebBackground Heart failure increases autonomic nerve activities and changes intracellular calcium (Ca i ) dynamics. Objective The purpose of this study was to investigate the hypothesis that abnormal Ca i dynamics are responsible for triggered activity in the pulmonary veins (PVs) during acetylcholine infusion in a canine model of heart failure.

WebDec 1, 2010 · Canine model of pacing-induced HF. All animal study protocols were approved by the Institutional Animal Care and Use Committee of Indiana University … hashing in advance data structureWebMay 10, 2016 · In pacing-induced canine models of heart failure, marked upregulation of adenosine A1 receptors occurs with increased sensitivity to adenosine induced SN dysfunction and AF. 67. Download figure; Download PowerPoint; Figure 4. Rhythm strip showing the effect of adenosine on the sinus node and atrium. Intravenous adenosine … hashing in blockchainWebJan 20, 1998 · Pacing-induced heart failure is characterized by defects in nitric oxide generation, 14 and this alteration may increase the respiratory activity of mitochondria … hashing in c++ javatpoint boolle shooterWebMar 19, 1999 · Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca2+ handling have not been investigated in this model. bool learningWebFeb 18, 2014 · Some patients even develop severely depressed LV function within a short time frame, a condition that has been coined ‘dyssynchronopathy’ in a canine model of AV block that develops rapid heart failure. 10 Development of a dyssynchronopathy might also explain the well-known but ill-defined group of super-responders to CRT. 11 It should be ... hashing in c javatpointWeb20 hours ago · Abnormal mitochondrial function in myocardium of dogs with chronic heart failure. J Mol Cell Cardiol. 1998; 30:1757–1762. doi: 10.1006/jmcc.1998.0739 Crossref Medline Google Scholar; 105. Marin-Garcia J, Goldenthal MJ, Moe GW. Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure. … bool linguagem c